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Havi AlGhosain
Havi AlGhosain
Institution
Brown University, Department of Biomedical Engineering
Introduction
Havi is a translational biomedical engineer with a PhD and experience in medical device design, in-vivo biocompatibility, and safety evaluation. His background includes industry collaboration with Medtronic and device development from user needs through prototype validation. He has expertise in biomaterial-tissue interactions, preclinical testing, experimental design, and regulatory-aware research, including ISO 10993 and FDA class II considerations. In his free time, he enjoys cooking, reading, and scuba diving in the Red Sea.
Top Fields
Engineering, Biology & Life Sciences, Medicine & Public Health
Research Areas
This mentor can support students interested in nanomedicine, nanotoxicology, drug delivery, bioimaging, safety and biocompatibility, and biomedical imaging. They are also comfortable mentoring projects related to medical device design, prototyping, diagnostics, pre-diagnostic devices, biostatistics, and experimental design.
Nanomedicine and Nanotoxicology
Drug Delivery and Bioimaging
Safety and Biocompatibility
Medical Device Design and Prototyping
Diagnostics and Pre-Diagnostic Devices
Biomedical Imaging
Biostatistics
Experimental Design
Background
Havi served as Lead Research Scientist on the Photonic Retinal Prosthesis project at Brown University from 2019 to 2025, where he designed and executed preclinical in-vivo studies evaluating biocompatibility, systemic toxicology, and performance of nanomaterial-based systems for retinal prosthesis development. His work included serum biochemistry and hematological biomarker analysis, quantitative imaging workflows for 3D retinal nanoparticle distribution, integration of confocal and two-photon microscopy datasets, and first-in-field systemic toxicity studies of intravitreal gold nanorods published in ACS Nano and Toxicological Research.
He also served as Chief Scientific Officer for CranioFix through the NEMIC Med Tech Leadership Program, where he helped develop an enhanced extra-ventricular drainage device by translating neurosurgical user needs into engineering design inputs and supporting prototype design, validation, and regulatory positioning. Earlier, as a Lead Design Intern at Medtronic, he led the redesign of a laparoscopic specimen removal device, with the final prototype adopted and commercialized by Medtronic.
Lead Research Scientist, Photonic Retinal Prosthesis, Brown University 2019 – 2025
• Designed and executed pre-clinical in-vivo studies to evaluate biocompatibility, systemic toxicology, and performance of nanomaterial-based systems for the development of a retinal prosthesis, aligning protocols with FDA class II and ISO 10993- 11 frameworks
• Led systemic toxicity evaluation through serum biochemistry and hematological biomarker analysis following intravitreal exposure
• Lead researcher on a $2 million NIH R01 project; directed study design, budgeting and cross-institutional collaboration
• Developed quantitative imaging workflows enabling 3D mapping of retinal nanoparticle distribution to assess delivery
efficiency
• Integrated confocal and two-photon microscopy datasets to validate in-vivo localization and improve layer-specific resolution
• Authored first-in-field systemic toxicity studies of intravitreal gold nanorods (ACS Nano, Toxicological Research)
Chief Scientific Officer CranioFix, Providence, RI (NEMIC Med Tech Leadership Program) 2021 – 2022
• Led development of an enhanced extra-ventricular drainage device, translating neurosurgical user needs into engineering design inputs
• Contributed to prototype design and iterative validation, aligning technical development with clinical and regulatory considerations
• Coordinated cross-functional teams (engineering, clinical, IP) to support feasibility, design refinement, and regulatory positioning
Lead Design Intern Medtronic, Whitehaven, CT 2016 – 2017
• Led re-design of a laparoscopic specimen removal device (ReliaCatchTM), translating surgeon feedback into engineering
specifications
• Final prototype was adopted and commercialized by Medtronic